Dynamically Reconfigurable Online Self-organising Fuzzy Neural Network with Variable Number of Inputs for Smart Home Application

A self-organising fuzzy-neural network (SOFNN) adapts its structure based on variations of the input data. Conventionally in such self-organising networks, the number of inputs providing the data is fixed. In this paper, we consider the situation where the number of inputs to a network changes dynamically during its online operation. We extend our existing work on a SOFNN such that the SOFNN can self-organise its structure based not only on its input data, but also according to the changes in the number of its inputs. We apply the approach to a smart home application, where there are certain situations when some of the existing events may be removed or new events emerge, and illustrate that our approach enhances cognitive reasoning in a dynamic smart home environment. In this case, the network identifies the removed and/or added events from the received information over time, and reconfigures its structure dynamically. We present results for different combinations of training and testing phases of the dynamic reconfigurable SOFNN using a set of realistic synthesized data. The results show the potential of the proposed method

UAV Formation Control under Fixed and Variable Adjacency based Directed Network Topologies

The UAV formation control is one of the key aspects in several applications like surveillance, moving target tracking, load-transportation, and delivery systems etc. These situations demand the multiple UAVs to manoeuvre in a desired formation. To address this problem, a distributed formation control scheme is proposed incorporating the details about the state of the neighbouring UAVs. The communication network topology among the UAVs is considered to be directed with the constant and the weighted adjacency matrices. The nonholonomic constraints are considered while deriving the desired Euler angles. Satisfying the conditions of Lyapunov provides necessary proof of stability along the positional and the attitude subsystems. Simulation results demonstrate that the desired tetrahedron, octahedron, and cube shapes are attained and maintained by the UAVs successfully. Also, the designed formation paradigm works proficiently for both the constant and the weighted adjacency matrices based directed network topologies. The performance validation is done through extensive comparative analysis for varying network connections

Kinetička svojstva F-centara pod utjecajem topline

The migration of colour clouds after the electron injection in pure and doped KCl and KBr alkali halides under thermal and field stresses is studied with an anode contact of spherical geometry. The diffusion coefficient of the colour clouds has been obtained using a derived analytical expression and the experimental data, and the activation energy of the colour centre was estimated. The dissociation energy values under thermal and field stresses for doped crystals are deduced through the mobility transport equation. The results indicate the effect of doping in an otherwise pure counterpart of the same crystals.Proučavamo premještanje oblaka boje nakon ubacivanja elektrona u čiste i punjene kristale alkalnih halida KCl i KBr, pod djelovanjem topline i električnog polja, uz primjenu kuglaste elektrode. Pomoću izvedene analitičke relacije i mjernih podataka odredili smo koeficijent difuzije oblaka boje i ocijenili aktivacijsku energiju centara boje. Primjenom jednadžbe pokretljivosti izveli smo vrijednosti disocijacijske energije pod toplinskim i električnim naprezanjem za punjene kristale. Podaci pokazuju učinak punjenja u odnosu na čiste kristale

Kinetička svojstva F-centara pod utjecajem topline

The migration of colour clouds after the electron injection in pure and doped KCl and KBr alkali halides under thermal and field stresses is studied with an anode contact of spherical geometry. The diffusion coefficient of the colour clouds has been obtained using a derived analytical expression and the experimental data, and the activation energy of the colour centre was estimated. The dissociation energy values under thermal and field stresses for doped crystals are deduced through the mobility transport equation. The results indicate the effect of doping in an otherwise pure counterpart of the same crystals.Proučavamo premještanje oblaka boje nakon ubacivanja elektrona u čiste i punjene kristale alkalnih halida KCl i KBr, pod djelovanjem topline i električnog polja, uz primjenu kuglaste elektrode. Pomoću izvedene analitičke relacije i mjernih podataka odredili smo koeficijent difuzije oblaka boje i ocijenili aktivacijsku energiju centara boje. Primjenom jednadžbe pokretljivosti izveli smo vrijednosti disocijacijske energije pod toplinskim i električnim naprezanjem za punjene kristale. Podaci pokazuju učinak punjenja u odnosu na čiste kristale

Lignin Residue-Derived Carbon-Supported Nanoscale Iron Catalyst for the Selective Hydrogenation of Nitroarenes and Aromatic Aldehydes

Heterogeneous iron-based catalysts governing selectivity for the reduction of nitroarenes and aldehydes have received tremendous attention in the arena of catalysis, but relatively less success has been achieved. Herein, we report a green strategy for the facile synthesis of a lignin residue-derived carbon-supported magnetic iron (γ-Fe2O3/LRC-700) nanocatalyst. This active nanocatalyst exhibits excellent activity and selectivity for the hydrogenation of nitroarenes to anilines, including pharmaceuticals (e.g., flutamide and nimesulide). Challenging and reducible functionalities such as halogens (e.g., chloro, iodo, and fluoro) and ketone, ester, and amide groups were tolerated. Moreover, biomass-derived aldehyde (e.g., furfural) and other aromatic aldehydes were also effective for the hydrogenation process, often useful in biomedical sciences and other important areas. Before and after the reaction, the γ-Fe2O3/LRC-700 nanocatalyst was thoroughly characterized by X-ray diffraction (XRD), N2adsorption-desorption, X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HR-TEM), Raman spectroscopy, and thermogravimetric analysis (TGA). Additionally, the γ-Fe2O3/LRC-700 nanocatalyst is stable and easily separated using an external magnet and recycled up to five cycles with no substantial drop in the activity. Eventually, sustainable and green credentials for the hydrogenation reactions of 4-nitrobenzamide to 4-aminobenzamide and benzaldehyde to benzyl alcohol were assessed with the help of the CHEM21 green metrics toolkit. © 2022 American Chemical Society. All rights reserved

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

A novel resource aware scheduling with multi-criteria for heterogeneous computing systems

Multi-criteria scheduling for heterogeneous computing systems (HCSs) is one of the prime concerns of modern computing world. It is an NP-complete problem. In this paper, we have proposed two resource aware multi-criteria scheduling, where scheduling is done by considering real-time resources such as, clock frequency, memory capacity and residual energy. The proposed algorithms are designed using four conflicting objectives, viz., minimization of makespan, energy-consumption, load-balancing, and maximization of resource utilization. The proposed work is analyzed and validated by extensive simulations with synthetic as well as benchmark data sets. Through the simulation results, it is observed that the proposed work has considerable improvements over Min–Min, MCT, Genetic algorithm (GA) and priority based performance improved algorithm (PPIA). A statistical hypothesis test Analysis of Variance (ANOVA) and post hoc test are performed to demonstrate the effectiveness of the proposed work. Keywords: Scheduling cost, Makespan, Energy-consumption, Load-balancing, Heterogeneous computing system

UAV Formation Control under Fixed and Variable Adjacency based Directed Network Topologies

1285-1296The UAV formation control is one of the key aspects in several applications like surveillance, moving target tracking, load-transportation, and delivery systems etc. These situations demand the multiple UAVs to manoeuvre in a desired formation. To address this problem, a distributed formation control scheme is proposed incorporating the details about the state of the neighbouring UAVs. The communication network topology among the UAVs is considered to be directed with the constant and the weighted adjacency matrices. The nonholonomic constraints are considered while deriving the desired Euler angles. Satisfying the conditions of Lyapunov provides necessary proof of stability along the positional and the attitude subsystems. Simulation results demonstrate that the desired tetrahedron, octahedron, and cube shapes are attained and maintained by the UAVs successfully. Also, the designed formation paradigm works proficiently for both the constant and the weighted adjacency matrices based directed network topologies. The performance validation is done through extensive comparative analysis for varying network connections

CEFTRIAXONE RELATED ADVERSE DRUG REACTIONS IN CHILDREN IN A TERTIARY CARE HOSPITAL, KOLKATA, WEST BENGAL, INDIA

Ceftriaxone is a third-generation cephalosporin antibiotic, which has broad-spectrum activity against Gram-positive and Gram-negative bacteria. It is a frequently used antibiotic in children worldwide. Studies revealed a number of adverse reactions related to this third generation antibiotic. A survey was done where data related with adverse drug reactions (ADRs) were collected for three months from the Department of Pediatrics of a tertiary care hospital, Kolkata, West Bengal, India and then evaluated. In the study, fifteen ADRs were detected. Ceftriaxone itself or its combinations correlated with more than thirty three percent (33.4%) adverse reaction cases in this study. Most common adverse drug reactions in the present study population were different types of rashes like urticaria and maculopapular eruptions